Paris, France – Prince Frederik of Luxembourg succumbed to complications of the rare genetic disorder POLG mitochondrial disease on March 1 in Paris. The news of his passing was shared by his family through the POLG Foundation’s website, which Frederik had initiated in 2022.

POLG mitochondrial disease is described as a genetic disorder that depletes the body’s cells of energy, leading to progressive organ dysfunction and failure, with no known treatment or cure. Prince Robert of Luxembourg, Frederik’s father, expressed deep sorrow in announcing his son’s death, highlighting Frederik’s dedication as the founder and Creative Director of the POLG Foundation.

The foundation’s mission, as outlined by Prince Robert, is to pursue therapies and a potential cure to prevent other patients from enduring the suffering experienced by Frederik and their family. Tragically, Prince Frederik passed away just a day after Rare Disease Day, at a young age in his early 20s.

Frederik’s commitment to raising awareness and advocating for research into rare genetic disorders like POLG resonated deeply with those who knew him. His untimely death serves as a poignant reminder of the ongoing challenges faced by individuals battling such diseases and the urgent need for further medical advancements in this field.

The legacy of Prince Frederik of Luxembourg, his advocacy work, and the ongoing efforts of the POLG Foundation to combat mitochondrial disorders serve as a testament to his enduring impact on the medical community and the lives of those affected by rare genetic conditions. His memory will continue to inspire progress in research and treatment for rare diseases globally.